白念珠菌MAPK信号通路研究进展

摘要/Abstract

摘要： 白念珠菌是人类最常见的条件致病菌。促分裂素原活化蛋白激酶(MAPK链) 是真核生物信号传递网络中的重要途径之一,在基因表达调控和细胞质功能活动中发挥关键作用。在白念珠菌中主要有4条MAPK途径:Mkc1途径、Cek1途径、Cek2途径和HOG途径。其中HOG途径在白念珠菌MAPK信号通路起着重要的作用。对于白念珠菌MAPK信号通路的作用及相关调控机制的了解,可以为寻找新的药物作用靶点,治疗念珠菌病提供帮助。

关键词: 白念珠菌, MAPK信号通路, Hog途径

Abstract: Candida albicans is the most common opportunistic pathogen in humans. Mitogen-activated protein kinase (MAPK) chain is one of the most important ways of eukaryotic signal network and it plays a key role in regulating gene expression in the cytoplasm functions. There are mainly four MAPK signaling pathways in Candida albicans: Mkc1, Cek1, Cek2 and HOG. The HOG pathway plays an important role in MAPK signaling pathway of Candida albicans. The understanding about the role of MAPK signaling pathway in Candida albicans and related regulatory mechanism will provide help to find new drug targets and the treatment of candidiasis.

Key words: Candida albicans, MAPK signaling pathway, HOG pathway

中图分类号:

R379.4

王德, 黄欣, 赵力澜, 赵敬军. 白念珠菌MAPK信号通路研究进展[J]. 中国真菌学杂志, 2013, 8(4): 252-256.

WANG De, HUANG Xin, ZHAO Li-lan, ZHAO Jing-jun. Advances in the MAPK signaling pathway of Candida albicans[J]. Chinese Journal of Mycology, 2013, 8(4): 252-256.

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