烟曲霉关键致病因子研究进展

摘要/Abstract

摘要： 烟曲霉是侵袭性真菌病常见的致病菌之一。近年来一些细胞表面蛋白 (如GPI锚定蛋白)以及分泌的毒素被认为是烟曲霉的关键致病因子。现从烟曲霉的细胞壁蛋白、多糖,细胞外基质成分,烟曲霉的分泌产物几方面综述已发现的烟曲霉关键致病因子,并对未来的研究方向进行展望。

关键词: 烟曲霉, 致病因子, 细胞壁, 次级代谢产物

Abstract: The pathogenicity of Aspergillus fumigatus is due to its virulence factors. In recent years, some cell surface proteins (e.g. GPI-anchored protein) and toxins (e.g. gliotoxin) are regarded as the key virulence factors of A.fumigatus. In this article, we reviewed the key virulence factors of A.fumigatus and presented the prospect of future studies.

Key words: Aspergillus fumigatus, virulence factor, cell wall, secondary metabolite

中图分类号:

R379.6

贾震宇, 李德东, 姜远英, 王彦. 烟曲霉关键致病因子研究进展[J]. 中国真菌学杂志, 2013, 8(4): 241-245.

JIA Zhen-yu, LI De-dong, JIANG Yuan-ying, WANG Yan. Key virulence factors of Aspergillus fumigatus：an update[J]. Chinese Journal of Mycology, 2013, 8(4): 241-245.

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