医学真菌基因组研究进展(下)

中国真菌学杂志　 2013, Vol. 8 　Issue (4): 234-240.

医学真菌基因组研究进展(下)

占萍, 王冲, 刘维达

北京协和医学院, 中国医学科学院皮肤病研究所真菌科, 南京 210042

收稿日期:2013-04-26 出版日期:2013-08-28 发布日期:2013-08-28
通讯作者: 刘维达,E-mail:liumyco@hotmail.com E-mail:liumyco@hotmail.com
作者简介:占萍,女(汉族),博士,主治医师.E-mail:zhanping1980@163.com
基金资助:
国家973项目(2013CB531605)

The research advance of the medical fungal genomics

ZHAN Ping, WANG Chong, LIU Wei-da

Department of Mycology, Institute of Dermatology, Chinese Academy of Medical Science & Peking Union Medical College, Nanjing 210042, China

Received:2013-04-26 Online:2013-08-28 Published:2013-08-28

摘要/Abstract

摘要： 近年来,一系列重要医学致病真菌全基因组数据陆续被公布,使人类对这些致病菌的认识提高到全新水平。本文在回溯医学真菌基因组学和基因组测序技术发展历程、综述其发展现状及应用的基础上,再分别介绍重要医学真菌全基因组测序的进展。

关键词: 真菌, 全基因组测序, 念珠菌, 隐球菌, 曲霉, 青霉, 皮肤癣菌, 接合菌

Abstract: A serial of medical fungus genome data have been published in recent years, by which human can make a better understanding of the pathogenesis of these pathogens. Here we try to review the history of the medical fungal genomics,genome sequencing technology and introduce the development and progress of clinical important medical fungi genome.

Key words: fungi, whole genome sequencing, Candida, Cryptococcus, Aspergillus, Penicillium, Dermatophytes, Zygomycetes

中图分类号:

R379

占萍, 王冲, 刘维达. 医学真菌基因组研究进展(下)[J]. 中国真菌学杂志, 2013, 8(4): 234-240.

ZHAN Ping, WANG Chong, LIU Wei-da. The research advance of the medical fungal genomics[J]. Chinese Journal of Mycology, 2013, 8(4): 234-240.

参考文献

[1] Jones T, Federspiel NA, Chibana H,et al. The diploid genome sequence of Candida albicans[J].Proc Natl Acad Sci USA,2004, 101(19):7329-7334.
[2] Odds FC, Brown AJ, Gow NA. Candida albicans genome sequence: a platform for genomics in the absence of genetics[J]. Genome Biol,2004,5(7):230.
[3] 李筱芳,刘维达. 医学真菌基因组学的研究进展[J]. 微生物与感染,2006,1(1):53-56.
[4] Butler G, Rasmussen MD, Lin MF,et al. Evolution of pathogenicity and sexual reproduction in eight Candida genomes[J]. Nature.2009, 4,459(7247):657-662.
[5] Inglis DO, Arnaud MB, Binkley J,et al. The Candida genome database incorporates multiple Candida species: multispecies search and analysis tools with curated gene and protein information for Candida albicans and Candida glabrata [J].Nucleic Acids Res,2012,40(Database issue):D667-674.
[6] Sabiiti W, May RC. Mechanisms of infection by the human fungal pathogen Cryptococcus neoformans [J].Future Microbiol,2012,7(11):1297-1313.
[7] Loftus BJ, Fung E, RoncagliaP,et al. The genome of the basidiomycetous yeast and human pathogen Cryptococcus neoformans [J]. Science, 2005,25,307(5713):1321-1324.
[8] Lengeler KB, Fox DS, Fraser JA,et al. Mating-type locus of Cryptococcus neoformans : a step in the evolution of sex chromosomes[J]. Eukaryot Cell, 2002,1(5):704-718.
[9] D'Souza CA, Kronstad JW, Taylor G,et al. Genome variation in Cryptococcus gattii,an emerging pathogen of immunocompetenthosts[J]. MBio,2011,8,2(1):e00342-10.
[10] Nierman WC, Pain A, Anderson MJ,et al. Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus [J]. Nature,2005,22;438(7071):1151-1156.
[11] Bok JW, Balajee SA, Marr KA, et al. A regulator of morphogenetic fungal virulence factors[J].Eukaryot Cell,2005,4(9):1574-1582.
[12] Ronning CM, Fedorova ND, Bowyer P,et al. Genomics of Aspergillus fumigatus [J]. Rev Iberoam Micol,2005,22(4):223-228.
[13] Nierman WC, Pain A, Anderson MJ, et al. Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus [J]. Nature,2005,438(7071):1151-1156.
[14] Fedorova ND, Khaldi N, JoardarVS,etal.Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus [J]. PLoS Genet,2008,4(4):e1000046.
[15] JoardarV, Abrams NF, Hostetler J, et al.Sequencing of mitochondrial genomes of nine Aspergillus and Penicillium species identifies mobile introns and accessory genes as main sources of genome size variability[J]. BMC Genomics, 2012,13(1):698.
[16] Graser Y, Scott J, Summerbell R. The new species concept in dermatophytes-a polyphasic approach[J]. Mycopathologia,2008,166(5-6): 239-256.
[17] Achterman RR, White TC. A foot in the door for dermatophyte research[J]. PLoS Pathog,2012,8(3):e1002564.
[18] Burmester A, Shelest E, Glockner G, et al. Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi[J]. Genome Biol,2011,12(1):R7.
[19] The Broad Institute (2011) Dermatophyte Comparative Database. Available: http://www.broadinstitute.org/annotation/genome/dermatophyte_comparative/MultiHome.html. Accessed 2 March 2012.
[20] Heddergott C, Bruns S, Nietzsche S, et al. The Arthroderma benhamiae hydrophobin HypA mediates hydrophobicity and influences recognition by human immune effector cells[J]. Eukaryot Cell,2012,11(5):673-82.
[21] Martinez DA, Oliver BG, Graser Y, et al. Comparative genome analysis of Trichophyton rubrum and related dermatophytes reveals Candidate genes involved in infection[J]. MBio,2012,3(5):e00259-12.
[22] Machida M, Asai K, Sano M,et al. Genome sequencing and analysis of Aspergillusoryzae[J]. Nature,2005,438(7071):1157-1161.
[23] Woo PC, Lau SK, Liu B,et al. Draft genome sequence of Penicillium marneffei strain PM1[J]. Eukaryot Cell,2011,10(12):1740-1741.
[24] Xu J, Saunders CW, Hu P,et al. Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens[J]. Proc Natl Acad Sci USA,2007, 104(47):18730-1835.
[25] Ma LJ, van der Does HC, Borkovich KA,et al. Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium[J]. Nature,2010,464(7287):367-373.
[26] Sharpton TJ, Stajich JE, Rounsley SD, et al. Comparative genomic analyses of the human fungal pathogens Coccidioides and their relatives[J]. Genome Res,2009,19(10):1722-1731.
[27] Desjardins CA, Champion MD, Holder JW,et al. Comparative genomic analysis of human fungal pathogens causing paracoccidioidomycosis[J]. PLoS Genet, 2011,7(10):e1002345.
[28] Köser CU, Ellington MJ, Cartwright EJ, et al. Routine use of microbial whole genome sequencing in diagnostic and public health microbiology[J]. PLoS Pathog, 2012,8(8):e1002824.