关键词: 抗真菌药, 足癣, 治疗

Abstract: Objective To investigate the efficacy and safety of Meifute^® Antifungal Solution in the treatment of tinea pedis.Methods A open,multicentre trial was conducted in 5 muticentre.A total of 126 patients was enrolled.The patients with interdigital tinea pedis were applied once, and The patients with hyperkeratotic tinea pedis were applied twice interval of one week.Global efficacy,clinical improvement and mycological cure was assessed in terms of total symptom score (TSS), mycology determination (KOH and dermatophyte culture) at baseline, 1,2 and 3 weeks after treatment.Results After treatment, mycological cure rate was 92.86%,TSS in four interview point, was 10.12±3.25,4.95±2.72,2.63±1.99和1.24±1.53 respectively,demonstrate a decreasing tendency,there is a significant defference in TSS between before and after treatment (t=30.87,P<0.005). Cure rates, effective rates and improved rates were 40.48%,50.79% and 8.73% respectively,the global efficacy was 91.27%. Incidence of adverse events was low, and the symptoms, including pain (20 cases/time), pruritus (5 cases/time), edema (2 cases/time) causalgia (1 cases/time),is confined and self-regressive.Conclusion These findings indicate that Meifute^® Antifungal Solution was highly safe and effective in the treatment of tinea pedis.

Key words: antifungal agents, tinea pedis, therapies