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中国真菌学杂志 2013, Vol. 8  Issue (4): 202-204.

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胡桃楸提取物对体外白念珠菌生物膜形成的影响

俞晓丽, 闻平, 王君   

  1. 江苏大学附属人民医院检验科, 镇江 212002
  • 收稿日期:2012-12-20 出版日期:2013-08-28 发布日期:2013-08-28
  • 通讯作者: 闻平,E-mail:zjwenp@163.com E-mail:zjwenp@163.com
  • 作者简介:俞晓丽,女(汉族),本科,副主任技师.E-mail:zhjyuxiaoli@163.com

In vitro activity of Extracts of Juglans against Candida albicans biofilms

YU Xiao-li, WEN Ping, WANG Jun   

  1. Department of Clinical Laboratories, the affiliated pepoles hospital of Jiangsu Universty, Zhenjiang 212002, China
  • Received:2012-12-20 Online:2013-08-28 Published:2013-08-28

摘要: 目的 研究胡桃楸提取物对白念珠菌生物膜形成的影响。方法 采用甲基四氮盐 (XTT)还原法评价胡桃楸提取物对白念珠菌的生物膜形成及黏附性的影响。镜下观察胡桃楸提取物对白念珠菌生物膜的形态学影响。结果 胡桃楸提取物抑制白念珠菌生物膜50%及90%的最小抑制药物浓度 (SMIC50、SMIC90) 分别为15.2 μg、23.4 μg。胡桃楸提取物作用浓度大于20 μg时对该菌细胞黏附有抑制作用。30 μg胡桃楸提取物可完全抑制白念珠菌生物膜的形成。结论 胡桃楸提取物对体外白念珠菌生物的膜形成有较强的抑制作用。

关键词: 胡桃楸提取物, 白念珠菌, 生物膜

Abstract: Objective To investigate in vitro effects of Extracts of Juglans on C.albicans biofilms.Methods XTT reduction assay was performed to determine the effect of Extracts of Juglans on C.albicans biofilms and its adherence. The effect of Extracts of Juglans on morphogenesis of C.albicans biofilms was observed by inverted microscopy.Results SMIC50, SMIC90 of Extracts of Juglans against C.albicans biofilms was15.2 μg/mL, 23.4 μg/mL, respectively. Extracts of Juglans at the concentration of >20 μg/mL could inhibit the adherence of C.albicans.Extracts of Juglans at t he concentration of 30 μg/mL could inhibit biofilm formation totally.Conclusions Extracts of Juglans shows potential activity ag ainst C.albicans biofilm in the study.

Key words: Extracts of Juglans, C.albicans, biofilm

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