甲癣的病原学研究进展

中国真菌学杂志　 2013, Vol. 8 　Issue (2): 120-123.

甲癣的病原学研究进展

冯姣¹, 曾梅华¹, 陈军¹, 吴凡¹, 吕桂霞², 任芳¹, 桑红¹

1. 南京军区南京总医院, 南京 210002;
2. 中国医学科学院北京协和医学院皮肤病研究所, 南京 210042

收稿日期:2012-10-09 出版日期:2013-04-28 发布日期:2013-04-28
通讯作者: 桑红,E-mail:shzwqzsl@163.com E-mail:shzwqzsl@163.com
作者简介:冯姣,女 (汉族),硕士研究生在读.E-mail:ariesmodesty@foxmail.com

Advances in reasearch etiology of tinea unguium

FENG Jiao¹, ZENG Mei-hua¹, CHEN Jun¹, WU Fan¹, LV Gui-xia², REN Fang¹, SANG Hong¹

1. Department of Dermatology, Nanjing General Hospital of Nanjing Military Command, Nanjing 210002;
2. Institute of Dermatology, Chinese Academy of Medical Science & Peking Union Medical College, Nanjing 210042

Received:2012-10-09 Online:2013-04-28 Published:2013-04-28

摘要/Abstract

摘要： 甲真菌病是由皮肤癣菌、酵母菌及霉菌引起的甲板和甲下组织感染,皮肤癣菌是主要致病菌,其所致的甲真菌病称为甲癣。皮肤癣菌分为3个属:毛癣菌属、小孢子菌属和表皮癣菌属。随着医学真菌学基础知识的普及和真菌学诊疗水平的提高,越来越多的皮肤癣菌在甲中分离,临床上对甲癣致病真菌的正确鉴定对于制定治疗方案、评价预后以及流行病学监测等都有重要的指导意义。该文对国内外现有文献报道的甲癣的致病菌进行综述。

关键词: 甲癣, 甲真菌病, 皮肤癣菌

Abstract: Onychomycosis is a common infection of the nail plate or nail bed caused by dermatophytes, yeasts, and nondermatophyte molds. Dermatophytes are the major etiologic agents, Tinea unguium describes onychomycosis caused by a dermatophyte species. The dermatophytic fungi include numerous species of fungi which belong to three genera:Trichophyton, Microsporum, and Epidermophyton. With the popularity of the basic medical mycology and improvement of the fungi examination technology, more and more dermatophytic species were isolated from nails. Knowing the exact pathogen is important and has implications in therapy,prognosis and epidemiology. This article will review the pathogenic fungi of Tinea unguium which had been reported in the literature.

Key words: tinea unguium, onychomycosis, dermatophyte

中图分类号:

R756.4

冯姣, 曾梅华, 陈军, 吴凡, 吕桂霞, 任芳, 桑红. 甲癣的病原学研究进展[J]. 中国真菌学杂志, 2013, 8(2): 120-123.

FENG Jiao, ZENG Mei-hua, CHEN Jun, WU Fan, LV Gui-xia, REN Fang, SANG Hong. Advances in reasearch etiology of tinea unguium[J]. Chinese Journal of Mycology, 2013, 8(2): 120-123.

参考文献

[1] Ilkit M, Saracli M A, Yuksel T. Trichophyton rubrum with the 'raubitschekii' morphotype: the first report from Turkey[J]. Mycopathologia, 2011, 171(2): 119-122.
[2] 马蕾,李若瑜,余进,等. 红色毛癣菌raubitschekii变种致Majocchi肉芽肿一例[J]. 中华皮肤科杂志, 2008, 41(6): 364-366.
[3] 陈柏叡,李若瑜. 须癣毛癣菌分类进展[J]. 中国真菌学杂志, 2011(1): 51-56.
[4] Chadeganipour M, Nilipour S, Ahmadi G. Study of onychomycosis in Isfahan, Iran[J]. Mycoses, 2010, 53(2): 153-157.
[5] Sarma S, Capoor M R, Deb M, et al. Epidemiologic and clinicomycologic profile of onychomycosis from north India[J]. Int J Dermatol, 2008, 47(6): 584-587.
[6] Nkondjo M S, Fabrizi V, Papini M. Onychomycosis in Cameroon: a clinical and epidemiological study among dermatological patients[J]. Int J Dermatol, 2012, 51(12): 1474-1477.
[7] Aghamirian M R, Ghiasian S A. Onychomycosis in Iran: epidemiology, causative agents and clinical features[J]. Nihon Ishinkin Gakkai Zasshi, 2010, 51(1): 23-29.
[8] Adhikari L, Das G A, Pal R, et al. Clinico-etiologic correlates of onychomycosis in Sikkim[J]. Indian J Pathol Microbiol, 2009, 52(2): 194-197.
[9] Yenisehirli G, Bulut Y, Sezer E, et al. Onychomycosis infections in the Middle Black Sea Region, Turkey[J]. Int J Dermatol, 2009, 48(9): 956-959.
[10] 刘芳,孔庆涛,王雪连,等. 甲真菌病临床特点及致病菌谱的研究[J]. 临床误诊误治, 2012, 25(10): 88-92.
[11] Khanna D, Goel A, Kedar A, et al. Trichophyton tonsurans induced recurrent onychomadesis in a very young infant[J]. Pediatr Dermatol. 2012.
[12] 刘孝兵,杨帆,汤成利,等. 安康地区1000例甲真菌病病原菌分析[J]. 中国真菌学杂志, 2006(4): 221-222.
[13] Mapelli ET, Colombo L, Crespi E, et al. Toenail onychomycosis due to Trichophyton violaceum complex. (An unusual, emerging localization of this anthropophilic dermatophyle)[J]. Mycoses, 2012, 55(2): 193-194.
[14] Romano C, Massai L, Strangi R, et al. Tinea corporis purpurica and onychomycosis caused by Trichophyton violaceum[J]. Mycoses, 2011, 54(2): 175-178.
[15] Huang C C, Sun P L. Superficial white onychomycosis caused by Trichophyton verrucosum[J]. Int J Dermatol, 2008, 47(11): 1162-1164.
[16] Macura A B, Krzysciak P, Skora M, et al. Case report: onychomycosis due to Trichophyton schoenleinii[J]. Mycoses, 2012, 55(2): e18-e19.
[17] Tosti A, Baran R, Piraccini B M, et al. "Endonyx" onychomycosis: a new modality of nail invasion by dermatophytes[J]. Acta Derm Venereol, 1999, 79(1): 52-53.
[18] Neji S, Makni F, Cheikhrouhou F, et al. First case of Trichophyton soudanense isolated in Tunisia[J]. Mycopathologia, 2010, 170(5): 353-355.
[19] Huovinen S, Tunnela E, Huovinen P, et al. Human onychomycosis caused by Trichophyton equinum transmitted from a racehorse[J]. Br J Dermatol, 1998, 138(6): 1082-1084.
[20] Bonifaz A, Araiza J, Koffman-Alfaro S, et al. Tinea imbricata: autosomal dominant pattern of susceptibility in a polygamous indigenous family of the Nahuatl zone in Mexico[J]. Mycoses. 2004, 47(7): 288-291.
[21] Krentel G. Fungal flora of the nails in consideration of Trichophyton megninii[J]. Dermatol Monatsschr, 1970, 156(6): 627-634.
[22] 杨国玲,戴文英,林熙然. 猴类毛癣菌所致甲真菌病一例[J]. 中华皮肤科杂志, 1997(5): 66.
[23] 梁晓博,李廷慧,胡蓉,等. 637例甲真菌病临床类型及致病真菌分析[J]. 中国真菌学杂志, 2012, 07(05): 287-289.
[24] 罗宏. 湖南郴州地区某医院甲真菌病305例临床病原菌分析[J]. 中国皮肤性病学杂志, 2012, 26(07): 611-612.
[25] 马国群,戴唯. 761例甲真菌病病原菌分离培养分析[J]. 中华医院感染学杂志, 2011(3): 617-618.
[26] 占志萍,聂振华. 甲真菌病719例临床及致病真菌分析[J]. 中国皮肤性病学杂志, 2010(4): 324-325.
[27] 许素玲,林蕾,邵椒青,等. 宁波地区甲真菌病及其相关因素的调查分析[J]. 中国麻风皮肤病杂志, 2008(4): 280-282.
[28] Romano C, Massai L, Gallo A, et al. Microsporum gypseum infection in the Siena area in 2005-2006[J]. Mycoses, 2009, 52(1): 67-71.
[29] Garcia-Martos P, Gene J, Sole M, et al. Case of onychomycosis caused by Microsporum racemosum[J]. J Clin Microbiol, 1999, 37(1): 258-260.
[30] Poblete-Gutierrez P, Abuzahra F, Becker F, et al. Onychomycosis in a diabetic patient due to Trichophyton gallinae[J]. Mycoses, 2006, 49(3): 254-257.
[31] Otcenasek M, Sich J, Dvorak J.Combined dermatophytic nail infection due to Microsporum ferrugineum and Trichophyton rubrum[J]. Mykosen, 1971, 14(3): 111-113.