光动力治疗女性尖锐湿疣合并外阴阴道念珠菌病的临床疗效观察

中国真菌学杂志　 2013, Vol. 8 　Issue (2): 101-104.

光动力治疗女性尖锐湿疣合并外阴阴道念珠菌病的临床疗效观察

张云杰, 杨宇光, 郭小娟, 邹先彪

解放军总医院第一附属(304)医院皮肤科, 北京 100048

收稿日期:2012-11-27 出版日期:2013-04-28 发布日期:2013-04-28
通讯作者: 邹先彪,E-mail:xbzou@126.com E-mail:xbzou@126.com
作者简介:张云杰,男 (汉族),本科,主治医师.E-mail:zhangyunjie25@sina.com

Analysis of the efficacy of photodynamic therapy of condyloma acuminatum with vulvovaginal candidiasis of women infections

ZHANG Yun-jie, YANG Yu-guang, GUO Xiao-juan, ZOU Xian-biao

Derpatment of Dermatology, the Fist Affiliated Hospital, General Hosptial of PLA, Beijing 100048, China

Received:2012-11-27 Online:2013-04-28 Published:2013-04-28

摘要/Abstract

摘要： 目的评价5-氨基酮戊酸光动力治疗尖锐湿疣合并外阴阴道念珠菌病的临床疗效。方法治疗组66例患者采用光动力联合氟康唑胶囊和克霉唑栓,对照组50例患者采用冷冻联合氟康唑胶囊和克霉唑栓。结果治疗组尖锐湿疣完全反应率92.4%,对照组尖锐湿疣完全反应率78.0%,差异有统计学意义(χ²=4.978,P=0.026)。治疗组真菌感染治愈率97.0%,对照组真菌感染治愈率86.0%,差异有统计学意义(χ²=4.783,P=0.029)。随访6个月,治疗组尖锐湿疣复发率7.5%,对照组复发率24.0%,两组间差异有统计学意义(χ²=6.136,P=0.013)。随访2个月后复查真菌,治疗组真菌复发率4.5%,对照组复发率16.0%,治疗组复发率显著低于对照组,差异有统计学意义(χ²=4.349,P=0.037)。结论 5-氨基酮戊酸光动力联合抗真菌治疗尖锐湿疣合并外阴阴道念珠菌病的患者安全、有效、复发率低。

关键词: 尖锐湿疣, 5-氨基酮戊酸光动力, 外阴阴道念珠菌病, 氟康唑, 克霉唑栓

Abstract: Objective To evaluate the clinical effect of 5-ALA photodynamic therapy in treating patient of condyloma acuminatum (CA) with vulvovaginal candidiasis infections.Methods The 66 cases in treatment group were treated by photodynamic combined with antifungal therapy, while the 50 cases in control group by frozen combined with antifungal therapy.Results Complete response rate of treatment group was 92.4%, while that of control group was 78.0%. The difference was statistically significant (χ²=4.978, P=0.026); The cure rate of fungal infection of treatment group was 97.0%, while that of control group 86.0%. The difference was statistically significant (χ²=4.783, P=0.029). Patients were followed up for 6 months, the recurrence rate of condyloma of treatment group was 7.5%, the control group 24.0% (χ²=6.136, P=0.013). After 2 months of follow-up, the recurrence rate of fungi infection of treatment group was 4.5%, whlie the control group 16.0% (χ²=4.349, P=0.037).Conclusion 5-ALA photodynamic combined with antifungal is a safe and effective treatment of condyloma acuminatum (CA) with vulvovaginal candidiasis with low recurrence rate.

Key words: condyloma acuminatum, 5-ALA photodynamic, vulvovaginal candidiasis, fluconazole, clotrimazole

中图分类号:

R711.3

张云杰, 杨宇光, 郭小娟, 邹先彪. 光动力治疗女性尖锐湿疣合并外阴阴道念珠菌病的临床疗效观察[J]. 中国真菌学杂志, 2013, 8(2): 101-104.

ZHANG Yun-jie, YANG Yu-guang, GUO Xiao-juan, ZOU Xian-biao. Analysis of the efficacy of photodynamic therapy of condyloma acuminatum with vulvovaginal candidiasis of women infections[J]. Chinese Journal of Mycology, 2013, 8(2): 101-104.

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