模式识别受体在白念珠菌感染中的作用

中国真菌学杂志　 2013, Vol. 8 　Issue (1): 47-50,60.

模式识别受体在白念珠菌感染中的作用

姚响文, 曹颖瑛, 姜远英

第二军医大学药学院新药研究中心, 上海 200433

收稿日期:2012-09-04 出版日期:2013-02-28 发布日期:2013-02-28
通讯作者: 姜远英,E-mail:jiangyysmmu@sina.com E-mail:jiangyysmmu@sina.com
作者简介:姚响文,女(汉族),硕士研究生在读.E-mail:852701912@163.com
基金资助:
国家自然科学基金(81271798)

Received:2012-09-04 Online:2013-02-28 Published:2013-02-28

摘要/Abstract

摘要： 白念珠菌感染机体后,机体首先通过固有免疫系统来发挥抗真菌作用,模式识别受体是固有免疫细胞用于识别PAMPs的分子,其中Toll样受体和C型凝集素家族是识别白念珠菌的主要PRR。这两类受体被激活后,会通过信号通路启动机体固有免疫和适应性免疫系统,诱导相关细胞因子的产生,募集巨噬细胞、中性粒细胞等吞噬细胞来杀灭白念珠菌,同时,还可传递相关信号诱导Th1、Th2、Th17和Treg等适应性免疫细胞的活化,通过体液免疫和细胞免疫来发挥抗真菌作用,对模式识别受体与白念珠菌相互作用机制的研究对临床真菌病的免疫调节和治疗具有重要意义。

关键词: 白念珠菌, 模式识别受体, Toll样受体, C型凝集素家族

中图分类号:

R379.4

姚响文, 曹颖瑛, 姜远英. 模式识别受体在白念珠菌感染中的作用[J]. 中国真菌学杂志, 2013, 8(1): 47-50,60.

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