糖皮质激素与侵袭性真菌感染

中国真菌学杂志　 2012, Vol. 7 　Issue (6): 367-371.

糖皮质激素与侵袭性真菌感染

郝飞, 王莉, 周村建

第三军医大学西南医院皮肤科,重庆 400038

收稿日期:2012-03-31 出版日期:2012-12-28 发布日期:2012-12-28
作者简介:郝飞,男 (汉族),博士,主任医师,博士研究生导师.E-mail:haofei62@medmail.com.cn

Glucocorticoids and invasive fungal infections:a review

HAO Fei, WANG Li, ZHOU Cun-jian

Department of Dermatology,Southwest Hospital,Third Military Medical University,Chongqing 400038

Received:2012-03-31 Online:2012-12-28 Published:2012-12-28

摘要/Abstract

摘要：

糖皮质激素 (激素)是诱发真菌感染、特别是机会性真菌感染重要的因素,可通过抑制免疫反应的多个环节而影响真菌感染的发生与进程。内源性激素相关的疾病如Chushing综合征的患者,以及医源性皮质激素使用的患者均可成为真菌感染的易患人群。正确理解糖皮质激素免疫抑制作用和真菌感染发生的相互关系,可以提高对相关真菌感染的认识并针对性开展防治策略,改善激素应用条件下发生真菌感染的预后。

关键词: 糖皮质激素, 侵袭性真菌感染, 机会性感染

Abstract:

It is well-known that hyperglucocorticoids play an important role in inducing the fungal infection,especially opportunistic fungal infection,which is attributed to the complex dysregulation of immunity caused by glucocorticoids.The patients, both those with endogenous Cushing's syndrome and, those receiving exogenous glucocorticoid therapy, are especially at risk of invasive fungal infections. A better knowledge of the interplay between glucocorticoid-induced immunosuppression and invasive fungal infections should assist in earlier recognition and establishment of specific prevention and treatment strategies in order to improve outcomes of such infections.

Key words: glucocorticoids, invasive fungal infection, opportunistic infection

中图分类号:

R 756.6

郝飞, 王莉, 周村建. 糖皮质激素与侵袭性真菌感染[J]. 中国真菌学杂志, 2012, 7(6): 367-371.

HAO Fei, WANG Li, ZHOU Cun-jian. Glucocorticoids and invasive fungal infections:a review[J]. Chinese Journal of Mycology, 2012, 7(6): 367-371.

参考文献

[1] Lionakis M S ,Kontoyiannis D P. Glucocorticoids and invasive fungal infections
[J]. Lancet,2003,362(29): 1828-1838.

[2] Shimoyama M, Shimmura S, Tsubota K, et al. Suppression of nuclear factor kappa B and CD18-mediated leukocyte adhesion to the corneal endothelium by dexamethasone
[J]. Invest Ophthalmol Vis Sci, 1997,38(11): 2427-2431.

[3] Ray KP, Farrow S, Daly M, et al. Induction of the E-selectin promoter by interleukin 1 and tumour necrosis factor alpha,and inhibition by glucocorticoids
[J]. Biochem J, 1997, 328(3): 707-715.

[4] Prasada R, Devauxb F, Dhamgayea S,et al. Response of pathogenic and non-pathogenic yeasts to steroids
[J]. J Steroid Biochem Mol Biol, 2012,129 (1):61-69.

[5] Lanza L, Scudeletti M, Monaco E, et al. Possible differences in the mechanism(s) of action of different glucocorticoid hormone compounds
[J]. Ann N Y Acad Sci,1999, 876(1): 193-197.

[6] DeRijk RH, Schaaf M, de Kloet ER. Glucocorticoid receptor variants: clinical implications. J Steroid Biochem Mol Biol,2002, 81(1):103-122.

[7] Peter E, Bakri F, Ball DM,et al. Invasive pulmonary filamentous fungal infection in a patient receiving inhaled corticosteroid therapy
[J]. Clin Infect Dis,2002,35(1): 54-56.

[8] Marr KA, Carter RA, Boeckh M,et al. Invasive aspergillosis in allogeneic stem cell transplant recipients: changes in epidemiology and risk factors
[J]. Blood,2002,100(22): 4358-4366.

[9] Klein NC, Go Ch, Cunha BA. Infections associated with steroid use
[J].Infect Dis Clin North Am,2001.15(3): 423-432.

[10] Dojcinovic I, Richter M. Mucormycoses: serious complication of high-dose corticosteroid therapy for traumatic optic neuropathy
[J].Int J Oral Maxillofac Surg,2008,37(4): 391-394.

[11] Nucci M, Anaissie E, Queiroz-Telles, et al. Outcome predictors of 84 patients with hematologic malignancies and Fusarium infection.Cancer,2003, 98(2): 315-319.

[12] Lyytikainen O, Ruutu T, Volin L, et al. Late onset Pneumocystis carinii pneumonia following allogeneic bone marrow transplantation
[J].Bone Marrow Transplant,1996,17(7): 1057-1059.

[1]	丁翔宇, 贾晨虹, 张古英, 李倩, 刘艳辉. 普外科婴幼儿侵袭性真菌感染的高危因素分析与评分系统建立[J]. 中国真菌学杂志, 2020, 15(6): 331-337,353.
[2]	张园, 杜君洋, 李绘宇, 付彦凯, 粟艳, 周泽奇, 王瑶, 徐英春, 王贺. 陈雪红重症病毒性肺炎合并侵袭性真菌感染早期诊断的现状、问题和对策[J]. 中国真菌学杂志, 2020, 15(3): 189-192.
[3]	霍晓赛, 贺政新, 王缚鲲. 侵袭性念珠菌感染及其与定植的关系研究进展[J]. 中国真菌学杂志, 2020, 15(2): 125-128.
[4]	范欣, 郭莉娜, 杨洋, 张戈, 段思蒙, 张京家, 徐英春, 杨春霞. 侵袭性感染酵母菌流行病学及耐药性分析[J]. 中国真菌学杂志, 2020, 15(1): 10-14.
[5]	周怡宏, 鲁雁秋, 陈耀凯. 艾滋病合并马尔尼菲蓝状菌的诊治现状及研究进展[J]. 中国真菌学杂志, 2019, 14(5): 308-312.
[6]	左微, 肖青. 恶性血液肿瘤患者侵袭性真菌感染防治进展[J]. 中国真菌学杂志, 2018, 13(4): 252-256.
[7]	尚元元, 喻楠, 董灵娣, 李莎莎, 刘昱奚. 血浆(1-3)-β-D葡聚糖对院内侵袭性真菌感染诊断的临床价值[J]. 中国真菌学杂志, 2018, 13(3): 168-172.
[8]	徐明均, 张慧婷, 张玉洁, 徐玉洁, 孙小鹏, 马晓薇. 血浆1,3-β-D葡聚糖检测联合念珠菌评分对侵袭性真菌感染的诊断价值[J]. 中国真菌学杂志, 2018, 13(1): 11-14.
[9]	郭凯, 项珍珍, 桑军军, 陈莉. 烟曲霉播散性感染1例误诊分析[J]. 中国真菌学杂志, 2016, 11(6): 372-375.
[10]	黄劲龙, 肖世极, 田丽红, 张媛媛, 周华蓉, 沈建箴. 泊沙康唑预防侵袭性真菌感染的Meta分析[J]. 中国真菌学杂志, 2015, 10(6): 357-364.
[11]	王学莉, 伏添, 王成立, 胡文能, 张西京. 两性霉素B治疗侵袭性肺部真菌感染的临床分析[J]. 中国真菌学杂志, 2014, 9(3): 163-166.
[12]	刘耀婷, 陈险峰, 胡海清, 殷杏, 陈勇, 周庭银, 仲人前. 血浆(1,3)-β-D葡聚糖检测对器官移植患者侵袭性真菌感染诊断价值[J]. 中国真菌学杂志, 2013, 8(3): 151-155.
[13]	金丽娜, 杜鹃, 袁振刚, 张春阳, 傅卫军, 侯健. 多发性骨髓瘤并发上消化道侵袭性念珠菌病2例报道及文献复习[J]. 中国真菌学杂志, 2013, 8(2): 83-86.
[14]	余进, 牟向东, 万喆, 阙呈立, 李若瑜. 自身免疫性大疱病合并侵袭性肺曲霉病:3例报告[J]. 中国真菌学杂志, 2012, (4): 214-218.
[15]	郝飞. 对深部真菌病使用“侵袭性真菌感染” 诊断名称的质疑[J]. 中国真菌学杂志, 2012, 7(3): 129-131.