激素治疗大疱性疾病引起真菌感染回顾性分析

中国真菌学杂志　 2012, Vol. 　Issue (5): 280-283.

激素治疗大疱性疾病引起真菌感染回顾性分析

易雪梅, 丁杨峰, 马骏, 苏丽娜, 楼玮

上海市皮肤病医院, 上海 200050

收稿日期:2012-05-26 出版日期:2012-10-28 发布日期:2012-10-28
通讯作者: 丁杨峰,E-mail:dingyangfeng@hotmail.com E-mail:dingyangfeng@hotmail.com
作者简介:易雪梅,女(汉族),硕士,主治医师.E-mail:xuemei_yi@yahoo.com.cn

The retrospective analysis of hospital fungal infection in Bullous disease patients treated with corticosteroids

YI Xue-mei, DING Yang-feng, MA Jun, SU Li-na, LOU Wei

Shanghai Skin Disease hospital, Shanghai 200050

Received:2012-05-26 Online:2012-10-28 Published:2012-10-28

摘要/Abstract

摘要： 目的研究糖皮质激素治疗大疱性疾病患者发生医院真菌感染的病原菌分类、危险因素和防治对策。方法收集67例大疱性类天疱疮和38例天疱疮患者糖皮质激素治疗的临床资料,计算医院真菌感染率,分析相关危险因素。结果大疱性疾病患者糖皮质激素治疗出现医院真菌感染率达32.38%,口腔真菌感染率为27.61%,肺部真菌感染率为13.33%,主要病原菌分别为白念珠菌 (69.77%),热带念珠菌 (11.63%)和近平滑念珠菌 (6.98%)。糖皮质激素剂量、免疫抑制剂、抗生素、住院日及糖尿病病史明显增加真菌感染危险,其中免疫抑制剂、抗生素和糖尿病病史为独立危险因素。结论糖皮质激素治疗大疱性疾病患者院内真菌感染发生率高,免疫抑制剂、抗生素和糖尿病病史是其主要危险因素。

关键词: 大疱性疾病, 激素, 真菌感染, 防治

Abstract: Objective To investigate the risk factors, the pathogen classification,clinical characteristics and prevention countermeasures of hospital fungal infection in Bullous disease patients treated with corticosteroids.Methods Sixty-seven patients with bullous pemphigoid and 38 patients with pemphigus treated with glucocorticoid were enrolled in this study. Their clinical data were collected to calculate the rate of hospital fungal infection and analysize its related risk factors.Results The rate of hospital fungal infection was 32.38% in Bullous disease patients treated with corticosteroids. The rates of oral and pulmonary fungal infections were 27.61% and 13.33%, and the main pathogens included C. albicans (69.77%), C. tropical (11.63%) and C. parapsilosis (6.98%). The fungal infections were obviously associated with corticosteroids doses, inmunoinhibitors, antibiotics and the history of diabetes, and immune inhibitors, antibiotics. History of diabetes were considered as the independent risk factors.Conclusion A high incidence of fungal infection was found in Bullous disease patients treated with corticosteroids. The inmunoinhibitors, antibiotics and history of diabetes were the main risk factors.

Key words: Bullous disease, corticosteroids, fungal infection, prevention

中图分类号:

R519

易雪梅, 丁杨峰, 马骏, 苏丽娜, 楼玮. 激素治疗大疱性疾病引起真菌感染回顾性分析[J]. 中国真菌学杂志, 2012, (5): 280-283.

YI Xue-mei, DING Yang-feng, MA Jun, SU Li-na, LOU Wei. The retrospective analysis of hospital fungal infection in Bullous disease patients treated with corticosteroids[J]. Chinese Journal of Mycology, 2012, (5): 280-283.

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