关键词: HIV, 口咽, 鼻腔, 真菌感染

Abstract: Objective To investigate fungal positive isolating rate of oropharynx and nasal cavity of HIV infected patients.Methods Collected mucous membrane secretions of pharyngo-oral cavity ulcer, leukoplakia, angular cheilitis, pharynx-buccal region and concha nasalis inferior or middle nasal meatus of nasal cavity were inoculated into 1 mL SDA liquid medium directly. The centrifugated depositions were observed directly under microscopy and inoculated into CHROM agar in 37℃ for 48 h. The isolate might be inoculated into Czapek agar medium in 25℃ for 1 week if it was filamentous, then identified into species by colony morphology and structures observed under microscopy.Results Among 94 HIV infected patients, there were 62 patients (66%) who were positive for fungal culture of pharyngo-oral cavity and 65 strains were isolated. While for nasal cavity, 48 patients (51%) were positive and 57 strains were obtained.Conclusions HIV infected patients were immunocompromised and easy to get secondary fungus infection. The high fungal colonization rate in oropharynx and nasal cavity were precursory symptom of invasive fungal infection. The isolation ratio of Candida albicans were the highest, 61% and 33% for oropharynx and nasal cavity repectively.

Key words: HIV, oropharynx, nasal cavity, fungal infection