白念珠菌生物被膜的基因表达及相关基因研究进展

中国真菌学杂志　 2012, Vol. 　Issue (2): 125-128.

综述上一篇

白念珠菌生物被膜的基因表达及相关基因研究进展

商庆华¹, 曹颖瑛^1,2, 苗浩³, 姜远英^1,2

1. 福建中医药大学药学院中药学教研室, 福州 350000;
2. 第二军医大学药学院药理学教研室, 上海 200433;
3. 沈阳药科大学药学院药理学教研室, 沈阳 110016

收稿日期:2011-12-12 出版日期:2012-04-28 发布日期:2012-04-28
通讯作者: 姜远英,E-mail:jiangyuanying@126.com E-mail:jiangyuanying@126.com
作者简介:商庆华,女(汉族),硕士研究生在读.E-mail:qinghua_high@126.com

Biofilm gene expression and biofilm-related genes of Candida albicans:an update

SHANG Qing-hua¹, CAO Ying-ying^1,2, MIAO Hao³, JIANG Yuan-ying^1,2

1. Department of Pharmacy, Fujian Traditional Chinese Medicine University, Fuzhou 350000;
2. Department of Pharmacology, Second Military Medical University, Shanghai 200433;
3. Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang 110016, China

Received:2011-12-12 Online:2012-04-28 Published:2012-04-28

摘要/Abstract

摘要： 白念珠菌是一种条件性致病菌,可在人体植入性器械表面形成生物被膜。与浮游和以个体形式存在的白念珠菌相比,生物被膜在结构及功能上有很大差异,这种差异本质上是由基因表达决定的。近年来,研究者们试图通过芯片和基因敲除等技术手段,探索与白念珠菌生物被膜形成及耐药相关的基因,揭示其分子机制,寻找药物作用的新靶点。

关键词: 白念珠菌, 生物被膜, 基因表达

Abstract: Candida albicans is an opportunistic fungal pathogen with the ability to form biofilms on in-planted medical devices. Cells in biofilms display a phenotype that is markedly different from their planktonic and free-living counterparts in both form and function.Recent advances in microarray and genetic manipulation have begun to clarify the mechanisms that govern C.albicans biofilm development and acquisition of such unique phenotype. These studies are considered to be important in finding new targets of antifungal drugs.

Key words: Candida albicans, biofilm, gene expression

中图分类号:

R379.4

商庆华, 曹颖瑛, 苗浩, 姜远英. 白念珠菌生物被膜的基因表达及相关基因研究进展[J]. 中国真菌学杂志, 2012, (2): 125-128.

SHANG Qing-hua, CAO Ying-ying, MIAO Hao, JIANG Yuan-ying. Biofilm gene expression and biofilm-related genes of Candida albicans:an update[J]. Chinese Journal of Mycology, 2012, (2): 125-128.

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白念珠菌生物被膜的基因表达及相关基因研究进展

Biofilm gene expression and biofilm-related genes of Candida albicans:an update

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