模式识别受体-Dectin-1的研究进展

中国真菌学杂志　 2012, Vol. 　Issue (2): 121-124.

模式识别受体-Dectin-1的研究进展

易秀莉, 刘斌, 齐显龙

第四军医大学西京医院皮肤科, 西安 710063

收稿日期:2011-10-28 出版日期:2012-04-28 发布日期:2012-04-28
通讯作者: 齐显龙,E-mail:qixianlong@163.com E-mail:qixianlong@163.com
作者简介:易秀莉,女(汉族),硕士,技师.E-mail:xiuli212@163.com
基金资助:
国家自然科学青年基金(31000073)

Recent insights from Dectin-1-Pattern Recognition Receptor

YI Xiu-li, LIU Bin, QI Xiao-long

Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi'an 710063, China

Received:2011-10-28 Online:2012-04-28 Published:2012-04-28

摘要/Abstract

摘要： Dectin-1是主要表达于髓样细胞中的非Toll样模式识别受体,它能诱导自身胞内信号介导一系列细胞反应,在抗真菌免疫中发挥着重要的作用。该文对Dectin-1介导的信号途径,Dectin-1与其他模式识别受体的相互作用,Dectin-1在适应性免疫、抗微生物免疫中的作用予以综述。

关键词: Dectin-1, 信号传导, 适应性免疫, 抗微生物免疫

Abstract: The Dectin-1 is a non-Toll-like pattern recognition receptor expressed predominantly by myeloid cells, which can induce its own intracellular signalling and can mediate a variety of cellular responses, plays a key role in anti-fungal immunity. The recent studies have focused on the signalling pathways from Dectin-1, interactions between Dectin-1 and other PRRs, Dectin-1 and adaptive immunity and the role of Dectin-1 in anti-microbial immunity.

Key words: Dectin-1, signalling pathways, adaptive immunity, anti-microbial immunity

中图分类号:

R392.1

易秀莉, 刘斌, 齐显龙. 模式识别受体-Dectin-1的研究进展[J]. 中国真菌学杂志, 2012, (2): 121-124.

YI Xiu-li, LIU Bin, QI Xiao-long. Recent insights from Dectin-1-Pattern Recognition Receptor[J]. Chinese Journal of Mycology, 2012, (2): 121-124.

参考文献

[1] Medzhitov R. Recognition of microorganisms and activation of the immune response[J]. Nature, 2007, 449(7164):819-826.
[2] Brown GD. Dectin-1: a signalling non-TLR pattern-recognition receptor[J]. Nat Rev Immunol, 2006, 6(1):33-43.
[3] Tsoni SV, Brown GD. beta-Glucans and dectin-1[J]. Ann N Y Acad Sci, 2008, 1143:45-60.
[4] Vautier S, Sousa Mda G, Brown GD. C-type lectins, fungi and Th17 responses[J]. Cytokine Growth Factor Rev, 2010, 21(6):405-412.
[5] Rogers NC, Slack EC, Edwards AD, et al. Syk-dependent cytokine induction by Dectin-1 reveals a novel pattern recognition pathway for C type lectins[J]. Immunity, 2005, 22(4):507-517.
[6] Fuller GL, Williams JA, Tomlinson MG, et al. The C-type lectin receptors CLEC-2 and Dectin-1, but not DC-SIGN, signal via a novel YXXL-dependent signaling cascade[J]. J Biol Chem, 2007, 282(17):12397-12409.
[7] Gross O, Gewies A, Finger K, et al. Card9 controls a non-TLR signalling pathway for innate anti-fungal immunity[J]. Nature, 2006, 442(7103):651-656.
[8] Hara H, Ishihara C, Takeuchi A, et al. The adaptor protein CARD9 is essential for the activation of myeloid cells through ITAM-associated and Toll-like receptors[J]. Nat Immunol, 2007, 8(6):619-629.
[9] Gringhuis SI, den Dunnen J, Litjens M, et al. Dectin-1 directs T helper cell differentiation by controlling noncanonical NF-kappaB activation through Raf-1 and Syk[J]. Nat Immunol ,2009, 10(2):203-213.
[10] Goodridge HS, Simmons RM, Underhill DM. Dectin-1 stimulation by Candida albicans yeast or zymosan triggers NFAT activation in macrophages and dendritic cells[J]. J Immunol, 2007, 178(5):3107-3115.
[11] Trinchieri G, Sher A. Cooperation of Toll-like receptor signals in innate immune defence[J]. Nat Rev Immunol, 2007, 7(3):179-190.
[12] Netea MG, Gow NA, Munro CA, et al. Immune sensing of Candida albicans requires cooperative recognition of mannans and glucans by lectin and Toll-like receptors[J]. J Clin Invest, 2006, 116(6):1642-1650.
[13] Dennehy KM, Ferwerda G, Faro-Trindade I, et al. Syk kinase is required for collaborative cytokine production induced through Dectin-1 and Toll-like receptors[J]. Eur J Immunol, 2008, 38(2):500-506.
[14] Ferwerda G, Meyer-Wentrup F, Kullberg BJ, et al. Dectin-1 synergizes with TLR2 and TLR4 for cytokine production in human primary monocytes and macrophages[J]. Cell Microbiol, 2008, 10(10):2058-2066.
[15] Taylor PR, Brown GD, Herre J, et al. The role of SIGNR1 and the beta-glucan receptor(dectin-1) in the nonopsonic recognition of yeast by specific macrophages[J]. J Immunol, 2004, 172(2):1157-1162.
[16] Valera I, Fernandez N, Trinidad AG, et al. Costimulation of dectin-1 and DC-SIGN triggers the arachidonic acid cascade in human monocyte-derived dendritic cells[J]. J Immunol, 2008, 180(8):5727-5736.
[17] Mantegazza AR, Barrio MM, Moutel S, et al. CD63 tetraspanin slows down cell migration and translocates to the endosomal-lysosomal-MIICs route after extracellular stimuli in human immature dendritic cells[J]. Blood, 2004, 104(4):1183-1190.
[18] Meyer-Wentrup F, Figdor CG, Ansems M, et al. Dectin-1 interaction with tetraspanin CD37 inhibits IL-6 production[J]. J Immunol, 2007, 178(1):154-162.
[19] LeibundGut-Landmann S, Gross O, Robinson MJ, et al. Syk-and CARD9-dependent coupling of innate immunity to the induction of T helper cells that produce interleukin 17[J]. Nat Immunol, 2007, 8(6):630-638.
[20] Acosta-Rodriguez EV, Rivino L, Geginat J, et al. Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells[J]. Nat Immunol, 2007, 8(6):639-646.
[21] Osorio F, LeibundGut-Landmann S, Lochner M, et al. DC activated via dectin-1 convert Treg into IL-17 producers[J]. Eur J Immunol, 2008, 38(12):3274-3281.
[22] Leibundgut-Landmann S, Osorio F, Brown GD, et al. Stimulation of dendritic cells via the dectin-1/Syk pathway allows priming of cytotoxic T-cell responses[J]. Blood, 2008, 112(13):4971-4980.
[23] Carter RW, Thompson C, Reid DM, et al. Preferential induction of CD4+ T cell responses through in vivo targeting of antigen to dendritic cell-associated C-type lectin-1[J]. J Immunol, 2006, 177(4):2276-2284.
[24] Yoshitomi H, Sakaguchi N, Kobayashi K, et al. A role for fungal {beta}-glucans and their receptor Dectin-1 in the induction of autoimmune arthritis in genetically susceptible mice[J]. J Exp Med, 2005, 201(6):949-960.
[25] Weck MM, Appel S, Werth D, et al. hDectin-1 is involved in uptake and cross-presentation of cellular antigens[J]. Blood, 2008, 111(8):4264-4272.
[26] Saijo S, Fujikado N, Furuta T, et al. Dectin-1 is required for host defense against Pneumocystis carinii but not against Candida albicans[J]. Nat Immunol, 2007, 8(1):39-46.
[27] Taylor PR, Tsoni SV, Willment JA, et al. Dectin-1 is required for beta-glucan recognition and control of fungal infection[J]. Nat Immunol, 2007, 8(1):31-38.
[28] Steele C, Rapaka RR, Metz A, et al.The beta-glucan receptor dectin-1 recognizes specific morphologies of Aspergillus fumigatus[J]. PLoS Pathog, 2005, 1(4):e42.
[29] Netea MG, Marodi L. Innate immune mechanisms for recognition and uptake of Candida species[J]. Trends Immunol, 2010, 31(9):346-353.
[30] Wheeler RT, Kombe D, Agarwala SD, et al. Dynamic, morphotype-specific Candida albicans beta-glucan exposure during infection and drug treatment[J]. PLoS Pathog, 2008, 4(12):e1000227.
[31] Wheeler RT, Fink GR. A drug-sensitive genetic network masks fungi from the immune system[J]. PLoS Pathog, 2006, 2(4):e35.
[32] Hohl TM, Feldmesser M, Perlin DS, et al. Caspofungin modulates inflammatory responses to Aspergillus fumigatus through stage-specific effects on fungal beta-glucan exposure[J]. J Infect Dis, 2008, 198(2):176-185.
[33] Lamaris GA, Lewis RE, Chamilos G, et al.Caspofungin-mediated beta-glucan unmasking and enhancement of human polymorphonuclear neutrophil activity against Aspergillus and non-Aspergillus hyphae[J]. J Infect Dis, 2008, 198(2):186-192.
[34] Shin DM, Yang CS, Yuk JM, et al. Mycobacterium abscessus activates the macrophage innate immune response via a physical and functional interaction between TLR2 and dectin-1[J]. Cell Microbiol, 2008, 10(8):1608-1621.
[35] Rothfuchs AG, Bafica A, Feng CG, et al. Dectin-1 interaction with Mycobacterium tuberculosis leads to enhanced IL-12p40 production by splenic dendritic cells[J]. J Immunol, 2007, 179(6):3463-3471.
[36] Yadav M, Schorey JS. The beta-glucan receptor dectin-1 functions together with TLR2 to mediate macrophage activation by mycobacteria[J]. Blood, 2006, 108(9):3168-3175.