大鼠白念珠菌支气管肺感染时肺组织Toll样受体2的表达及意义

中国真菌学杂志　 2011, Vol. 6 　Issue (6): 337-340.

大鼠白念珠菌支气管肺感染时肺组织Toll样受体2的表达及意义

林莉, 王莉, 周洋洋, 陈耀华, 孟新丽, 康健

中国医科大学第一临床医院呼吸内科呼吸疾病研究所, 沈阳, 110001

收稿日期:2011-08-01 出版日期:2011-12-28 发布日期:2011-12-28
通讯作者: 王莉,E-mail:wanglizsb@hotmail.com E-mail:wanglizsb@hotmail.com
作者简介:林莉,女(汉族),硕士,助教.E-mail:thinciya@126.com

TLR2 expression in rats with Candida albicans infection in lung

LIN Li, WANG Li, ZHOU Yang-yang, CHEN Yao-hua, MENG Xin-li, KANG Jian

Department of respiratory, the first affiliated hosipital of China Medical University, Shenyang, 110001, China

Received:2011-08-01 Online:2011-12-28 Published:2011-12-28

摘要/Abstract

摘要： 目的探讨Toll样受体2(TLR2)在白念珠菌支气管肺感染大鼠肺组织模型中的表达及意义。方法建立白念珠菌支气管肺感染大鼠模型,观察感染后肺组织病理形态学改变,采用免疫组织化学法观察感染后不同时间(第3天、第7天)白念珠菌支气管肺感染大鼠肺组织TLR2的表达,并与未感染组进行比较。结果大鼠白念珠菌支气管肺感染后肺组织TLR2表达水平明显升高。结论白念珠菌支气管肺感染肺组织TLR2表达增高可能参与感染的炎症反应。

关键词: 白念珠菌, 感染, Toll样受体2

Abstract: Objective To explore the expression of TLR2 in rats with Candida albicans infection in lung.Method Rats model of Candida albicans infection in lung was set up and changes in pathology were observed.TLR2 expression in the tissues at different timepoints were also observed by immunohis to chemical method.Results The expression of TLR2 in the lung of Candida albicans infected rats was significaltly higher than that in healthy rats.Conclusions Over expression of TLR2 in Candida albicans infected rats may related to inflammatory reaction.

Key words: Candida albicans, infection, Toll like receptor2

中图分类号:

R519

林莉, 王莉, 周洋洋, 陈耀华, 孟新丽, 康健. 大鼠白念珠菌支气管肺感染时肺组织Toll样受体2的表达及意义[J]. 中国真菌学杂志, 2011, 6(6): 337-340.

LIN Li, WANG Li, ZHOU Yang-yang, CHEN Yao-hua, MENG Xin-li, KANG Jian. TLR2 expression in rats with Candida albicans infection in lung[J]. Chinese Journal of Mycology, 2011, 6(6): 337-340.

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