真菌GXM生物学活性及影响因素的研究进展

中国真菌学杂志　 2011, Vol. 6 　Issue (5): 308-311.

真菌GXM生物学活性及影响因素的研究进展

聂建巍¹, 杨蓉娅²

1. 北京军区总医院全军皮肤病诊治中心, 北京100125;
2. 安徽医科大学, 安徽230032

收稿日期:2010-11-04 出版日期:2011-10-28 发布日期:2011-10-28
通讯作者: 杨蓉娅,E-mail:yangrya@sina.com E-mail:yangrya@sina.com
作者简介:聂建巍,女(汉族),硕士研究生在读.E-mail:jieshuijingling114@126.com
基金资助:
国家自然科学基金(81071304)

Received:2010-11-04 Online:2011-10-28 Published:2011-10-28

摘要/Abstract

摘要： 葡萄糖醛酸木糖甘露聚糖(GXM)是新生隐球菌(C.neoformans)荚膜的主要成分,经研究发现GXM也存在于毛孢子菌中,是阿萨希毛孢子菌(T.asahii)细胞壁的重要组成成分,与真菌的毒力和致病性密切相关。本文介绍了真菌GXM的生物学活性与影响因素,为真菌的检测及临床致病性研究提供理论依据。

关键词: 真菌, GXM, 生物学活性, 影响因素

中图分类号:

R379

聂建巍, 杨蓉娅. 真菌GXM生物学活性及影响因素的研究进展[J]. 中国真菌学杂志, 2011, 6(5): 308-311.

[1] McFadden DC,Freis BC,Wang F,et al.Capsule structural heterogeneity and antigenic variation in Cryptococcus neoformans[J].Eukaryot Cell,2007,6(8):1464-1473.
[2] Zaragoza O,Rodrigues ML,De JM,et al.The capsule of the fungal pathogen Cryptococcus neoformans[J].Adv Appl Microbiol,2009,68:133-216.
[3] Saha DC,Xess I,Zeng WY,et al.Antibody responses to Cryptococcus neoformans in Indian patients with cryptococcosis[J].Med Mycol,2008,46(5):457-463.
[4] Fonseca FL,Frases S,Casadevall A,et al.Structural and functional properties of the Trichosporon asahii glucuronoxylomannan[J].Fungal Genet Biol,2009,46(6-7):496-505.
[5] McFadden DC,Freis BC,Wang F,et al.Capsule structural heterogeneity and antigenic variation in Cryptococcus neoformans[J].Eukaryot Cell,2007,6(8):1464-1473.
[6] Pietrella D,Lupo P,Fries B,et al.Phenotypic switching of Cryptococcus neoformans can influence the outcome of the human immune response[J].Cell Microbiol,2003,5 (8):513-522.
[7] Vecchiarelli A.Immunoregulation by capsular components of Cryptococcus neoformans[J].Med Mycol,2000,38 (6):407-417.
[8] Goldman DL,Lee SC,Casadevall A.Tissue localization of Cryptococcus neoformans glucuronoxylomannan in the presence and absence of specific antibody[J].Infect Immun,1995,63(9):3448-3453.
[9] Vecchiarelli A,Monari C.Microbial polysaccharide:new insights for treating autoimmune diseases[J].Front Biosci,2010,1 (2):256-267.
[10] Yauch LE,Lam JS,Levitz SM.Direct inhibition of T-cell responses by the Cryptococcus capsular polysaccharide glucuronoxylomannan[J].PLoS Pathog,2006,2(11):120.
[11] Monari C,Pericolini E,Bistoni G,et al.Cryptococcns neoformans capsular glucuronoxylomannan induces expression of Fas ligand in macrophages[J].J Immunol,2005,174 (6):3461-3468.
[12] Vecchiarelli A,Pietrella D,Lupo P,et al.The polysaccharide capsule of Cryptococcus neoformans interferes with human dendritic cell maturation and activation[J]. J Leukocyte Biol,2003,74 (3):370-378.
[13] Monari C,Bistoni F,Vecchiarelli A.Glucuronoxylomannan exhibits potent immunosuppressive properties[J].FEMS Yeast Res,2006,6(4):537-542.
[14] Monad C,Bevilacqua S,Piccioni M,et al.A microbial polysaccharide reduces the severity of rheumatoid arthritis by influencing Th17 differentiation and proinflammatory cytokines production[J].J Immunol,2009,183(1):191-200.
[15] Maxson ME,Cook E,Casadevall A,et al.The volume and hydration of the Cryptococcus neoformans polysaccharide capsule [J].Fungal Genet Biol,2007,44(3):180-186.
[16] Rodrigues ML,Nakayasu ES,Oliveira DL,et al.Extracellular vesicles produced by Cryptococcus neoformans contain protein components associated with virulence[J]. Eukaryot Cell,2008,7(1):58-67.
[17] 王高峰,孔庆涛,王雪连,等.新生隐球菌荚膜研究现状[J].中国真菌学杂志,2010,5(5):312-314.
[18] Oliveira DL,Nimrichter L,Miranda K,et al. Cryptococcus neoformans cryoultramicrotomy and vesicle fractionation reveals an intimate association between membrane lipids and glucuronoxylomannan[J].Fungal Genet Biol,2009,46(12):956-963.
[19] Nimrichter L,Frases S,Cinelli LP,et al.Self-aggregation of Cryptococcus neoformans capsular glucuronoxylomannan is dependent on divalent cations[J].Eukaryotic Cell,2007,6(8):1400-1410.
[20] Diane C,Mc F,Oscar Z,et al.Immunoreactivity of Cryptococcal antigen is not stable under prolonged incubations in human serum[J].J Clin Microbiol,2004,42(6):2786-2788.
[21] Bryan RA,Zaragoza O,Zhang T,et al.Radiological studies re-veal radial differences in the architecture of the polysaccharide capsule of Cryptococcus neoformans[J].Eukaryot Cell,2005,4 (2):465-475.
[22] Rodrigues ML,Alvarez M,Fonseca FL,et al.Binding of the wheat germ lectin to Cryptococcus neoformans suggests an association of chitinlike structures with yeast budding and capsular glucuronoxylomannan[J].Eukaryot Cell,2008,7 (4):602-609.
[23] Karashima R,Yamakani Y,Yamagata E,et al.Increased release of glucuronoxylomannan antigen and induced pbenotypic changes in Trichosporon asahii by repeated passage in mice[J].Med Microbiol,2002,51(5):423-432.
[24] Fries BC,Goldman DL,Cherniak R,et al.Phenotypic switching in Cryptococcus neoformans results in changes in cellular morphology and gluculonoxylomannan structure[J].Infect Immun,1999,67(11):6076-6083.
[25] Beenhouwer DO,Yoo EM,Lai CW,et al.Human immunoglobulin G2 (IgG2) and IgG4,but not IgG1 or IgG3,protect mice against Cryptococcus neoformans infection[J].Infect Immun,2007,75(3):1424-1435.

真菌GXM生物学活性及影响因素的研究进展

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

本文评价

[1]	丁翔宇, 贾晨虹, 张古英, 李倩, 刘艳辉. 普外科婴幼儿侵袭性真菌感染的高危因素分析与评分系统建立[J]. 中国真菌学杂志, 2020, 15(6): 331-337,353.
[2]	李嘉利, 王鹏, 曾飞鹏. 红色毛癣菌致儿童阴囊、阴茎癣1例[J]. 中国真菌学杂志, 2020, 15(6): 364-365.
[3]	朱红梅, 温海. 特比萘芬在皮下及深部真菌感染中的临床应用[J]. 中国真菌学杂志, 2020, 15(6): 374-377.
[4]	刘瞳瞳, 杜琨. 施慧早产儿侵袭性真菌感染的危险因素[J]. 中国真菌学杂志, 2020, 15(6): 381-384.
[5]	特比萘芬临床应用专家共识工作组. 特比萘芬临床应用专家共识[J]. 中国真菌学杂志, 2020, 15(5): 257-261.
[6]	王玲, 景东云, 王学军, 刘俊, 曹月清. 长脉宽Nd:YAG 1064 nm激光治疗远端侧位甲下型甲真菌病的疗效观察及对真菌超微结构的影响[J]. 中国真菌学杂志, 2020, 15(5): 268-273.
[7]	陈易鑫, 闫师玲, 朱银民, 范静平, 陈晓平, 周恩晖, 薛晓成, 张燚. 真菌性鼻-鼻窦炎的CT影像诊断分析[J]. 中国真菌学杂志, 2020, 15(5): 283-287.
[8]	程颖, 陈丹. 儿童浅部真菌感染的临床分析[J]. 中国真菌学杂志, 2020, 15(5): 288-292.
[9]	朱红梅, 温海. 特比萘芬在浅表真菌感染中的临床应用[J]. 中国真菌学杂志, 2020, 15(5): 297-303.
[10]	赵静宇, 高杨杰, 甘厚婷, 陈润润, 顾菊林. 微课、慕课及翻转课堂在医学真菌学继续教育中的应用分析[J]. 中国真菌学杂志, 2020, 15(5): 304-305.
[11]	步青云, 王润超, 罗亭, 卢昌佩, 景海霞. 甲真菌病的激光治疗新进展[J]. 中国真菌学杂志, 2020, 15(5): 310-313.
[12]	李颖, 王贺, 张戈, 刘文静, 徐英春. Sensititre YeastOne显色药敏板与微量肉汤稀释法检测曲霉体外抗真菌药物敏感性的一致性研究[J]. 中国真菌学杂志, 2020, 15(4): 197-201.
[13]	赵颖, 李志荣, 赵建宏, 栗方, 董爱英, 刘金禄, 郭彦言, 谢守军, 吴相锟, 郭秀华, 王建升, 张金艳, 刘冬青, 魏宏莲, 孙艳, 赵文申, 任宏涛, 郭映辉, 肖盟, 徐英春, 徐晓琳, 王军爽, 杨文航. 河北地区临床实验室丝状真菌分离鉴定情况分析[J]. 中国真菌学杂志, 2020, 15(4): 206-212.
[14]	黄丽, 龚豪, 张春莲, 方彩云. 非妊娠妇女阴道真菌感染情况调查[J]. 中国真菌学杂志, 2020, 15(4): 213-217.
[15]	刘小平. 216例感染性皮肤病几种病原体镜检方法对比[J]. 中国真菌学杂志, 2020, 15(4): 223-226.