关键词: 隐球菌性脑膜炎合并肺炎, 肾移植, 治疗

Abstract: Objective To investigate the diagnosis and treatment of cryptococcal meningitis complicated with pneumonia after kidney transplantation.Methods One case of cryptococcal meningitis complicated with pneumonia after kidney transplantation was reported and related literatures were reviwed.Result The clinical symptoms (headache,nausea and vomiting,cough and expectoration etc) and the lung lesions in CT imaging disappeared after induction therapy with amphotericin B liposome and voriconazole and maintenance therapy with voriconazole.The acute rejection was abscent during the course of treatment.Conclusions As the clinical findings of kidney transplant recipients with cryptococcal meningitis complicated with pneumonia are non-specific,CSF india ink stain and latex agglutination test for cryptococcal antigen should be performed to establish an early diagnosis.Timely diagnosis and antifungal therapy are necessary of the prognosis.Immunosuppressive drugs should be adjusted depending the progress of antifungal therapy.

Key words: cryptococcal meningitis complicated with pneumonia, kidney transplantation, therapy