关键词: 播散性隐球菌病, 新生隐球菌grubii变种, 氟康唑, 红皮病

Abstract: Objective To report a case of disseminated cryptococcosis with related laboratory investigations.Methods A 72-year-old man was admitted due to erythroderma with multiple nodules and ulcers on the limbs.The diagnosis was confirmed by CT,biopsy,tissue culture,urease test and PCR sequencing anglysis.Results Skin tissue biopsy showed plenty of fungal components.Tissue culture produced yeast-like colony,which was positive in urease test.The strain was identified as Cryptococcus neoformans var.grubii by sequencing of ribosomal internal transcribed spacer region.Specific cryptococcal antigen test of serum showed strong positive result (++++).Chest CT indicated pulmonary cavity in the posterior basal segment of the left lung.The patient was finally diagnosed as disseminated cryptococcosis caused by Cryptococcus neoformans var.grubii.Conclusions Clinical and laboratory studies of this case assisted diagnosis of disseminated cryptococcosis.Microdissection and ITS region sequencing are promising approaches for diagnosis of fungal infections.

Key words: disseminated cryptococcosis, Cryptococcus neoformans var.grubii, fluconazole, erythroderma