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中国真菌学杂志 2011, Vol. 6  Issue (3): 162-165.

病例报告 上一篇    下一篇

三角孢小囊菌导致的心内膜炎1例

王澎, 王贺, 赵颖, 张小江, 徐英春   

  1. 中国医学科学院北京协和医院检验科临床微生物专业组, 北京, 100730
  • 收稿日期:2010-12-05 出版日期:2011-06-28 发布日期:2011-06-28
  • 通讯作者: 徐英春,E-mail:xycpumch@yahoo.com.cn E-mail:xycpumch@yahoo.com.cn
  • 作者简介:王澎,女(汉族),学士,主管技师.E-mail:PUMCH2005@126.com

A case of endocarditis caused by Microascus trigonosporus

WANG Peng, WANG He, ZHAO Ying, ZHANG Xiao-jiang, XU Ying-chun   

  1. Department of Clinical Laboratory, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China
  • Received:2010-12-05 Online:2011-06-28 Published:2011-06-28

摘要: 本文报道1例继发于植入心脏起搏器所致的三角孢小囊菌(Microascus trigonosporus)心内膜炎,此菌分离自患者起搏器电极表面的赘生物。赘生物组织病理切片显示大量有隔真菌丝,间生膨大的厚壁孢子。小囊菌系帚霉菌(Scopulariopsis)的有性阶段,广泛存在于自然界。目前国外已有短帚霉菌(Scopulariopsis brevicaulis)导致的心内膜炎报告[1-3],然而由小囊菌(Microascus)导致的心内膜炎非常罕见[4]。该菌株经ITS区测序比对,鉴定结果为三角孢小囊菌(Microascus trigonosporus),采用Etest法测定伊曲康唑的MIC≥32μg/mL,两性霉素B的MIC≥32μg/mL,而伏立康唑的MIC为4μg/mL。患者手术摘除赘生物,采用伏立康唑治疗,体温恢复正常,预后良好。

关键词: 三角孢小囊菌, 真菌心内膜炎, 侵袭性真菌感染

Abstract: A case of endocarditis caused by Microascus trigonosporus related was reported.The strain was isolated from the pacemaker surface and identified as Microascus trigonosporus by ITS analysis.Histopathology showed abundant septate hyphae and intercalary swollen chlamydospores in the vegetaion.Microascus trigonosporus widely spread in the natural world was anamorphs(asexual forms) of Scopulariopsis.Endocarditis caused by Microascus was rarely reported.Etest showed the MICs of itraconazole and amphotericin B were ≥32 μg/mL,while the MIC of voriconazole was 4 μg/mL.The patient improved by vegetation removal and itroconazole treatment.

Key words: Microascus trigonosporus, fungal endocarditis, invasive fungal infection

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