伊曲康唑联合特比萘芬治疗孢子丝菌病疗效及其对病原真菌体外抗菌活性研究

中国真菌学杂志　 2011, Vol. 6 　Issue (1): 5-9.

伊曲康唑联合特比萘芬治疗孢子丝菌病疗效及其对病原真菌体外抗菌活性研究

王爱平, 高那, 刘伟, 万喆, 陈伟, 涂平, 李若瑜

北京大学第一医院皮肤性病科, 北京大学真菌和真菌病研究中心, 北京, 100034

收稿日期:2010-09-19 出版日期:2011-02-28 发布日期:2011-02-28
作者简介:王爱平,女(汉族),学士,主任医师,硕士研究生导师.E-mail:wangap@medmail.com.cn

Combination of itraconazole and terbinafine in treating sporotrichosis and their in vitro antifungal activities against Sporothrix schenckii

WANG Ai-ping, GAO Na, LIU Wei, WAN Zhe, CHEN Wei, TU Ping, LI Ruo-yu

Department of Dermatology and Venereology, Peking University First Hospital, Peking University Research Center for Medical Mycology, Beijing 100034, China

Received:2010-09-19 Online:2011-02-28 Published:2011-02-28

摘要/Abstract

摘要： 目的初步探讨伊曲康唑和特比萘芬联合治疗孢子丝菌病的疗效,评价两药体外联合对申克孢子丝菌菌丝相和酵母相的抗菌活性。方法口服伊曲康唑200 mg/d和特比萘芬250 mg/d治疗孢子丝菌病;体外联合药敏试验采用棋盘微量稀释法,计算分数抑菌浓度(FIC)指数判定两药相互作用具有协同、拮抗或无关作用。结果伊曲康唑和特比萘芬联合成功治愈3例经伊曲康唑治疗无效的孢子丝菌病患者。两药体外联合对申克孢子丝菌菌丝相具有75%的协同作用,对酵母相为70%(P=0.50)。结论初步研究显示伊曲康唑和特比萘芬联合治疗孢子丝菌病有效安全,体外联合药敏试验显示两药具有较高的协同作用。

关键词: 孢子丝菌病, 伊曲康唑, 特比萘芬, 申克孢子丝菌, 菌丝相, 酵母相, 联合药敏, 协同作用

Abstract: Objective To evaluate the efficacy of the combination of itraconazole and terbinafine in treating sporotrichosis and against Sporothrix schenckii growing in both mycelial and yeast phases.Methods The combination of itraconazole(200 mg/d) and terbinafine(250 mg/d) was applied in the treatment of sporotrichosis.In vitro effects against Sporothrix schenckii in two growth phases were evaluated by checker-board method,and fractional inhibitory concentration(FIC) index was caculated to determine whether the interaction was synergistic,indifference,or antagonistic.Results Three patients failed in itraconazole therapy were cured with the combination of itraconazole and terbinafine.Synergistic interactions of itraconazole and terbinafine against Sporothrix schenckii in mycelial form and in yeast form,were observed to be 75% and 70% respectively(P=0.50).Conclusions The combination of itraconazole and terbinafine is efficient and safe in treating sporotrichosis with perfect synergy.

Key words: sporotrichosis, itraconazole, terbinafine, Sporothrix schenckii, mycelial form, yeast form, combination drug susceptibility testing, synergistic interactions

中图分类号:

R756.6

王爱平, 高那, 刘伟, 万喆, 陈伟, 涂平, 李若瑜. 伊曲康唑联合特比萘芬治疗孢子丝菌病疗效及其对病原真菌体外抗菌活性研究[J]. 中国真菌学杂志, 2011, 6(1): 5-9.

WANG Ai-ping, GAO Na, LIU Wei, WAN Zhe, CHEN Wei, TU Ping, LI Ruo-yu. Combination of itraconazole and terbinafine in treating sporotrichosis and their in vitro antifungal activities against Sporothrix schenckii[J]. Chinese Journal of Mycology, 2011, 6(1): 5-9.

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