关键词: Fonsecaea monophora, 着色芽生菌病, 伊曲康唑, 特比萘芬

Abstract: Objective To report a case of chromoblastomycosis caused by Fonsecaea monophora in North China and related laboratory investigation.Methods A 58-year-old man was admitted with skin granulomatous lesions on the right wrist for 8 to 9 years.Histopathologic examination,direct smear examination and fungal culture,PCR and ribosomal internal transcribed spacer(ITS)sequence analysis were performed for diagnosis.Results Sclerotic bodies were observed by direct smear examination.Histopathologic examination showed chronic granuloma and round,thick-walled sclerotic bodies.Fungal culture produced olivaceous to black colonies.Rhinocladiella type and cladosporium type conidia were observed in the slide culture identified as Fonsecaea monophora by sequence analysis of ITS region.After treatment with itraconazole(200 mg,QD)combined with terbinafine(250 mg,QD)for 3 months,the patient diagnosed as chromoblastomycosis caused by Fonsecaea monophora was cured.Conclusions Chromoblastomycosis caused by Fonsecaea monophora exists in North China,which can be identified by ITS analysis.Itraconazole with terbinafine has good effect.

Key words: Fonsecaea monophora, chromoblastomycosis, itraconazole, terbinafine