多育赛多孢菌性鼻窦炎1例——致病菌的鉴定和体外抗真菌药物敏感性研究

中国真菌学杂志　 2010, Vol. 5 　Issue (1): 1-4.

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多育赛多孢菌性鼻窦炎1例——致病菌的鉴定和体外抗真菌药物敏感性研究

帕丽达·阿布利孜¹, Takashi Yaguchi², 罗德梅¹, 惠艳¹, Katsuhiro Kamei², Kazuko Nishimura²

1. 新疆医科大学第一附属医院皮肤科, 乌鲁木齐, 830053;
2. 日本国立千叶大学真菌医学研究中心, 千叶, 日本, 260-8673

收稿日期:2009-03-01 出版日期:2010-02-28 发布日期:2010-02-28
通讯作者: 帕丽达#阿布利孜,女(维吾尔族),博士后,副主任医师.E-mai:lpalidaa@yahoo.com.cn E-mail:lpalidaa@yahoo.com.com
作者简介:帕丽达·阿布利孜,女(维吾尔族),博士后,副主任医师.E-mail:palidaa@yahoo.com.cn
基金资助:
新疆少数民族科技人才特殊培养基金(200823113)

A case report of sinusitis due to Scedosporium prolificans:identification of causative agent and antifungal susceptibility testing in vitro

Paride Abliz¹, Takashi Yaguchi², LUO De-mei¹, Yan Hui¹, Katsuhiro Kamei², Kazuko Nishimura²

1. Department of Dermatology, The First Hospital, Xinjiang Medical University, Urumqi 830053, China;
2. Medical Mycology Research Center Chiba University, 1-8-1 Inohana, Chuoku, 260-8673 Chiba, Japan

Received:2009-03-01 Online:2010-02-28 Published:2010-02-28

摘要/Abstract

摘要： 目的报告国内首例多育赛多孢菌致鼻窦炎,并探讨致病菌的鉴定及其对抗真菌药物体外敏感性。方法取患者左侧上颌窦分泌物进行真菌培养和形态学鉴定,分离菌株β-球蛋白、rDNAITS序列分析确切鉴定,对分离菌进行7种抗真菌药体外药敏试验。结果根据菌株的形态学特点和基因序列结果鉴定为多育赛多孢菌。体外药敏试验显示该菌对7种抗真菌药物耐药。结论多育赛多孢菌所致的真菌病较少见,其确切鉴定靠形态学特征和基因分析。该菌株对多种抗真菌药物耐药。

关键词: 多育赛多孢菌, 鼻窦炎, 致病菌鉴定, 体外药物敏感性

Abstract: Objective To report the first case of sinusitis caused by Scedosporium prolificans in China. To identify the causative agent and to study its untifungal succeptibility in vitro.Methods Maxillary excretion was drawn for cultivation and morphological identification. β-tublin and rDNA were isolated for ITS sequence analysis. Antifungal susceptibility was determined for 7 kinds of drug in vitro.Methods Scedosporium prolificans was identified by morphological characteristics and sequences data.Scedosporium prolificans was identified by morphological characteristics and sequences analysis.Conclusions Mycosis caused by Scedosporium prolificans is rare,identification of which is based on morphological characteristics and sequence analysis. This strain is resistant to many untifungal agents.

Key words: Scedosporium prolificans, sinusitis, identification of the causative agent, antifungal succeptibility in vitro

中图分类号:

R379.9

帕丽达·阿布利孜, Takashi Yaguchi, 罗德梅, 惠艳, Katsuhiro Kamei, Kazuko Nishimura. 多育赛多孢菌性鼻窦炎1例——致病菌的鉴定和体外抗真菌药物敏感性研究[J]. 中国真菌学杂志, 2010, 5(1): 1-4.

Paride Abliz, Takashi Yaguchi, LUO De-mei, Yan Hui, Katsuhiro Kamei, Kazuko Nishimura. A case report of sinusitis due to Scedosporium prolificans:identification of causative agent and antifungal susceptibility testing in vitro[J]. Chinese Journal of Mycology, 2010, 5(1): 1-4.

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多育赛多孢菌性鼻窦炎1例——致病菌的鉴定和体外抗真菌药物敏感性研究

A case report of sinusitis due to Scedosporium prolificans:identification of causative agent and antifungal susceptibility testing in vitro

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